Yes. The Patriot 16K has been designed to work with universal rail systems.
The Patriot 16K gives 3 inches of height adjustment, from 16" to 19" tall, and 4" of front to back adjustment. See the diagram for RV arm positions.
The short answer is yes, many folks towing fifth-wheel trailers with shortbed trucks successfully use the Patriot 16K.
There are many factors to consider when addressing the issue of cab clearance. To answer the question for you specific truck and trailer, pay attention to the following: